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"alzheimer" has 889 results in Products.

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ONO 2506

Cat. No. 4530/10
Description: Inhibits S-100β synthesis; neuroprotective
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AC 186

Cat. No. 5053/10
Description: Potent and selective ERβ agonist; neuroprotective
Purity: ≥99% (HPLC)
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PMX 205

Cat. No. 5196/1
Description: Potent C5a receptor peptide antagonist
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GTS 21 dihydrochloride

Cat. No. 4557/10
Description: α7 nAChR partial agonist
Purity: ≥98% (HPLC)
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SIB 1553A hydrochloride

Cat. No. 4764/10
Description: nAChR agonist; displays selectivity for β4 subunit-containing receptors
Purity: ≥98% (HPLC)
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LM11A 31 dihydrochloride

Cat. No. 5046/10
Description: Nonpeptide p75NTR ligand; neuroprotective
Purity: ≥95% (HPLC)
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Congo Red

Cat. No. 5167/50
Description: Amyloid fibril binding dye; also a VGlut inhibitor
Purity: ≥98% (HPLC)
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HNGF6A

Cat. No. 5154/1
Description: Humanin analog; increases insulin sensitivity
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FPS ZM1

Cat. No. 6237/10
Description: High affinity antagonist of RAGE
Purity: ≥99% (HPLC)
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ASP 2535

Cat. No. 5308/10
Description: Potent and selective GlyT1 inhibitor
Purity: ≥98% (HPLC)
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"alzheimer" has 8 results in Targets.

Alzheimer's Disease Research

Alzheimer's disease (AD), the most common type of dementia, is an irreversible and progressive neurodegenerative disorder causing cognitive and functional impairment. It is characterized by formation of protein aggregates and progressive loss of neurons in the central nervous system (CNS). The symptoms of AD include short-term memory loss, confusion, irritability, aggression and mood swings, progressing to long-term memory deficit, withdrawal from social interactions and subsequently a loss in higher central functioning.

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DYRK

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.

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ER Stress/Unfolded Protein Response

Endoplasmic reticulum (ER) stress occurs when the protein synthesis requirements of the cell exceed the protein folding capacity of the ER. Improperly folded proteins accumulate in the ER, which triggers the unfolded protein response (UPR) to restore ER homeostasis.

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Eph Receptors

Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.

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Kynurenine 3-monooxygenase

Kynurenine 3-monooxygenase (KMO, EC 1.14.13.9) is a 56 kDa flavoenzyme that catalyzes the hydroxylation of L-kynurenine (L-Kyn) to 3-hydroxykynurenine (3-HK) in the kynurenine pathway, the major route for tryptophan metabolism.

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Neuroinflammation

Neuroinflammation is a host-defense mechanism in the CNS, which protects normal brain function and structure in response to injury and infection. This may be beneficial by leading to the clearance of unwanted material and dying cells in healthy brain development, but also pathogenic in the induction of neuronal cell death and production of antibodies against CNS proteins.

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RAGE

The receptor for advanced glycation end-products (RAGE; AGER) is a multiligand cell surface protein belonging to the immunoglobulin (Ig) superfamily. RAGE acts as a pattern recognition receptor (PRR) and is involved in inflammation and the immune response.

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"alzheimer" has 2 results in Resources.

Alzheimer's Life Science Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

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Neurodegeneration Research Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
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