"alzheimer" has 820 results in Products.
AC 186
LM11A 31 dihydrochloride
PF 04449613
Congo Red
"alzheimer" has 8 results in Targets.
Alzheimer's Disease Research
Alzheimer's disease (AD), the most common type of dementia, is an irreversible and progressive neurodegenerative disorder causing cognitive and functional impairment. It is characterized by formation of protein aggregates and progressive loss of neurons in the central nervous system (CNS). The symptoms of AD include short-term memory loss, confusion, irritability, aggression and mood swings, progressing to long-term memory deficit, withdrawal from social interactions and subsequently a loss in higher central functioning.
More InfoDYRK
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.
More InfoER Stress/Unfolded Protein Response
Endoplasmic reticulum (ER) stress occurs when the protein synthesis requirements of the cell exceed the protein folding capacity of the ER. Improperly folded proteins accumulate in the ER, which triggers the unfolded protein response (UPR) to restore ER homeostasis.
More InfoEph Receptors
Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.
More InfoKynurenine 3-monooxygenase
Kynurenine 3-monooxygenase (KMO, EC 1.14.13.9) is a 56 kDa flavoenzyme that catalyzes the hydroxylation of L-kynurenine (L-Kyn) to 3-hydroxykynurenine (3-HK) in the kynurenine pathway, the major route for tryptophan metabolism.
More InfoNeuroinflammation
Neuroinflammation is a host-defense mechanism in the CNS, which protects normal brain function and structure in response to injury and infection. This may be beneficial by leading to the clearance of unwanted material and dying cells in healthy brain development, but also pathogenic in the induction of neuronal cell death and production of antibodies against CNS proteins.
More Info"alzheimer" has 2 results in Resources.
Alzheimer's Life Science Poster
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
More InfoNeurodegeneration Research Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease