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"RAS" has 10 results in Products.

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PSB 1114

Cat. No. 4333/1
Description: Potent, selective P2Y2 agonist
Chemical Name: 4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
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NF 546

Cat. No. 3892/10
Description: Selective P2Y11 agonist
Chemical Name: 4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt
Purity: ≥95% (HPLC)
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Cat. No. 6317/10
Description: Irreversible P2Y12 antagonist; antiplatelet and orally active
Purity: ≥98% (HPLC)
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PPADS tetrasodium salt

Cat. No. 0625/10
Description: Non-selective P2 antagonist
Chemical Name: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt
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2-Methylthioadenosine triphosphate tetrasodium salt

Cat. No. 1062/10
Description: Non-selective P2 agonist
Chemical Name: 2-Methylthioadenosine-5'-triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
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MRS 2179 tetrasodium salt

Cat. No. 0900/10
Description: Selective P2Y1 antagonist
Chemical Name: 2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt
Purity: ≥98% (HPLC)
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AR-C 66096 tetrasodium salt

Cat. No. 3321/1
Description: Potent and selective P2Y12 antagonist
Chemical Name: 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
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2-ThioUTP tetrasodium salt

Cat. No. 3280/1
Description: Potent and selective P2Y2 agonist
Chemical Name: 2-Thiouridine 5'-triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
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AR-C 69931 tetrasodium salt

Cat. No. 5720/1
Description: Highly potent P2Y12 antagonist
Chemical Name: N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine-5'-O-(β,γ-dichloromethylene)triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
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MRS 2768 tetrasodium salt

Cat. No. 3884/1
Description: Selective P2Y2 agonist
Chemical Name: Uridine-5'-tetraphosphate δ-phenyl ester tetrasodium salt
Purity: ≥98% (HPLC)
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"RAS" has 2 results in Targets.

Ras GTPases

Ras GTPases are prototypical members of the RAS superfamily and regulate cytosolic signaling pathways involved in gene expression, as well as regulation of cell proliferation, differentiation and survival. In humans there are 3 Ras genes, which are the most commonly identified oncogenes, found in approximately 20-30% of all cancers.

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Small Monomeric GTPases

Small monomeric GTPases (also known as small G-proteins) are homologous to Gα proteins. This family of GTPases includes the RAS superfamily, which is further split into subfamilies based on structural, sequence and functional similarities. Each subfamily of small GTPases plays a slightly different role in the regulation of intracellular signaling pathways and cellular processes.

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"RAS" has 1 results in Resources.

RAS Oncoproteins Scientific Review

Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.

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