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Products (11)
Targets (2)
Resources (1)

"RAS" has 11 results in Products.

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Deltarasin

Cat. No. 5424/10
Description: High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
Purity: ≥99% (HPLC)
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Kobe 0065

Cat. No. 5475/10
Description: H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
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KYA 1797K

Cat. No. 7002/5
Description: Wnt/β-catenin signaling inhibitor
Purity: ≥98% (HPLC)
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Erastin

Cat. No. 5449/10
Description: Mitochondrial VDAC modulator; also Ferroptosis activator
Purity: ≥98% (HPLC)
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DEL 22379

Cat. No. 5774/10
Description: ERK dimerization inhibitor
Purity: ≥98% (HPLC)
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Chicago Sky Blue 6B

Cat. No. 0846/1G
Description: Dye used as counterstain in histochemistry; also potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
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Oncrasin 1

Cat. No. 3427/10
Description: Induces abnormal nuclear aggregation of PKCι; proapoptotic
Purity: ≥98% (HPLC)
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Ponceau S Staining Solution

Cat. No. 5225/500ML
Description: Stain used to detect protein bands after Western blotting
Chemical Name: 3-Hydroxy-4-[2-[2-sulfo-4-[2-(4-sulfophenyl)diazenyl]phenyl]diazenyl]-2,7-naphthalenedisulfonic acid tetrasodium salt
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Phosphodiesterase Inhibitor Tocriset™

Cat. No. 1881/1 SET
Description: Selection of 5 phosphodiesterase inhibitors (Cat. Nos. 0915, 1504, 0415, 1349 and 1046)
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Evans Blue tetrasodium salt

Cat. No. 0845/1G
Description: Dye for assessing cell viability and blood brain barrier permeability; also EAAT inhibitor and iGluR antagonist
Chemical Name: 6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[4-amino- 5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt
Purity: ≥90% (HPLC)
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"RAS" has 2 results in Targets.

Ras GTPases

Ras GTPases are prototypical members of the RAS superfamily and regulate cytosolic signaling pathways involved in gene expression, as well as regulation of cell proliferation, differentiation and survival. In humans there are 3 Ras genes, which are the most commonly identified oncogenes, found in approximately 20-30% of all cancers.

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Small Monomeric GTPases

Small monomeric GTPases (also known as small G-proteins) are homologous to Gα proteins. This family of GTPases includes the RAS superfamily, which is further split into subfamilies based on structural, sequence and functional similarities. Each subfamily of small GTPases plays a slightly different role in the regulation of intracellular signaling pathways and cellular processes.

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"RAS" has 1 results in Resources.

RAS Oncoproteins Scientific Review

Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.

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