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Products (46)
Targets (2)
Resources (1)

"RAS" has 46 results in Products.

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Deltarasin

Cat. No. 5424/10
Description: High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
Purity: ≥99% (HPLC)
Pricing & Availability Qty

Kobe 0065

Cat. No. 5475/10
Description: H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
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KYA 1797K

Cat. No. 7002/5
Description: Wnt/β-catenin signaling inhibitor
Purity: ≥98% (HPLC)
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EHT 1864

Cat. No. 3872/10
Description: Potent Rac family inhibitor
Purity: ≥98% (HPLC)
Pricing & Availability Qty

Pluripotin

Cat. No. 4433/1
Description: Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal
Purity: ≥98% (HPLC)
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Ferrostatin 1

Cat. No. 5180/10
Description: Selective inhibitor of erastin induced ferroptosis
Purity: ≥98% (HPLC)
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Erastin

Cat. No. 5449/10
Description: Mitochondrial VDAC modulator; also Ferroptosis activator
Purity: ≥98% (HPLC)
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(S)-Crizotinib

Cat. No. 6025/10
Description: MTH1 inhibitor
Purity: ≥98% (HPLC)
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DEL 22379

Cat. No. 5774/10
Description: ERK dimerization inhibitor
Purity: ≥98% (HPLC)
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SCH 51344

Cat. No. 5280/10
Description: Potent MTH1 inhibitor
Purity: ≥99% (HPLC)
Pricing & Availability Qty
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"RAS" has 2 results in Targets.

Ras GTPases

Ras GTPases are prototypical members of the RAS superfamily and regulate cytosolic signaling pathways involved in gene expression, as well as regulation of cell proliferation, differentiation and survival. In humans there are 3 Ras genes, which are the most commonly identified oncogenes, found in approximately 20-30% of all cancers.

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Small Monomeric GTPases

Small monomeric GTPases (also known as small G-proteins) are homologous to Gα proteins. This family of GTPases includes the RAS superfamily, which is further split into subfamilies based on structural, sequence and functional similarities. Each subfamily of small GTPases plays a slightly different role in the regulation of intracellular signaling pathways and cellular processes.

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"RAS" has 1 results in Resources.

RAS Oncoproteins Scientific Review

Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.

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