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"RAS" has 43 results in Products.

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Cat. No. 4989/10
Description: Ras inhibitor; also induces autophagy
Purity: ≥98% (HPLC)
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Cat. No. 5411/10
Description: RalA and RalB inhibitor
Purity: ≥98% (HPLC)
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Cat. No. 5607/10
Description: Ras signaling inhibitor; inhibits Ack1 and GCK
Purity: ≥98% (HPLC)
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Fendiline Hydrochloride

Cat. No. 6407/10
Description: Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker
Purity: ≥98% (HPLC)
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ML 210

Cat. No. 6429/10
Description: Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
Purity: ≥98% (HPLC)
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FTI 277

Cat. No. 2407/1
Description: Prodrug form of FTI 276 (Cat. No. 2406)
Purity: ≥95% (HPLC)
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Cat. No. 5424/10
Description: High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
Purity: ≥99% (HPLC)
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Cat. No. 6920/500U
Description: KRas/SOS1 interaction inhibitor
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Zoledronic Acid

Cat. No. 6111/10
Description: Potent farnesyl diphosphate (FPP) synthase inhibitor
Purity: ≥98% (HPLC)
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BAY 293 Negative Control

Cat. No. 6906/5
Description: Negative control for BAY 293 (Cat. No. 6857)
Purity: ≥98% (HPLC)
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"RAS" has 2 results in Targets.

Ras GTPases

Ras GTPases are prototypical members of the RAS superfamily and regulate cytosolic signaling pathways involved in gene expression, as well as regulation of cell proliferation, differentiation and survival. In humans there are 3 Ras genes, which are the most commonly identified oncogenes, found in approximately 20-30% of all cancers.

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Small Monomeric GTPases

Small monomeric GTPases (also known as small G-proteins) are homologous to Gα proteins. This family of GTPases includes the RAS superfamily, which is further split into subfamilies based on structural, sequence and functional similarities. Each subfamily of small GTPases plays a slightly different role in the regulation of intracellular signaling pathways and cellular processes.

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"RAS" has 1 results in Resources.

RAS Oncoproteins Scientific Review

Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.

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