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"NOTCH3" has 3 results in Products.

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DBZ

Cat. No. 4489/10
Description: γ-secretase inhibitor; inhibits Notch pathway
Purity: ≥98% (HPLC)
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FLI 06

Cat. No. 5172/10
Description: Inhibitor of Notch signaling
Purity: ≥99% (HPLC)
Pricing & Availability Qty

Begacestat

Cat. No. 4283/10
Description: γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
Purity: ≥98% (HPLC)
Pricing & Availability Qty
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"NOTCH3" has 2 results in Targets.

γ-Secretase

γ-secretase is a multi-subunit internal protease that cleaves within the transmembrane domain of its substrates. It is an integral membrane protein and minimally consists of four proteins; presenilin, nicastrin, APH-1 and PEN-2. γ-secretase is involved in the processing of Notch.

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Notch Signaling

Notch is a transmembrane receptor that co-ordinates an important signaling cascade in all species. Notch signaling mediates local cell-to-cell communications as its ligands are mostly other transmembrane proteins, limiting the signaling to its neighboring cells.

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"NOTCH3" has 1 results in Resources.

Notch Signaling Pathway

The Notch pathway is involved in determination of cell fate, regulation of pattern formation and other developmental settings. Disrupted signaling can cause developmental defects and a range of adult pathologies.

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