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"2B13" has 66 results in Products.

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PPAHV

Cat. No. 1466/1
Description: Non-pungent vanilloid receptor agonist
Purity: ≥98% (HPLC)
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Phorbol 12-myristate 13-acetate

Cat. No. 1201/1
Description: Protein kinase C activator
Purity: ≥99% (HPLC)
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Dihydro-β-erythroidine hydrobromide

Cat. No. 2349/10
Description: Inhibitor of α4β2, muscle type and Torepedo nAChRs
Purity: ≥98% (HPLC)
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Celastrol

Cat. No. 3203/10
Description: Inhibits TNF-α-induced NF-κB activation
Purity: ≥99% (HPLC)
Pricing & Availability Qty

Pristimerin

Cat. No. 3731/10
Description: Potent, reversible MAGL inhibitor
Purity: ≥99% (HPLC)
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CL 316243 disodium salt

Cat. No. 1499/10
Description: Highly selective β3 agonist
Purity: ≥98% (HPLC)
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NSC 697923

Cat. No. 4858/10
Description: Selective UBE2N inhibitor
Purity: ≥98% (HPLC)
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(-)-Xestospongin C

Cat. No. 1280/10U
Description: Reported inhibitor of IP3-dependent Ca2+ release
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Noscapine hydrochloride

Cat. No. 1697/100
Description: Tubulin inhibitor; induces apoptosis
Purity: ≥99% (HPLC)
Pricing & Availability Qty

Flutax 1

Cat. No. 2226/1
Description: Fluorescent taxol derivative
Purity: ≥98% (HPLC)
Pricing & Availability Qty
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"2B13" has 13 results in Targets.

Bombesin Receptors

Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

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Calcium-Sensitive Proteases

Calpain and cathepsin are calcium-sensitive proteases. Calpains are a family of 14 cysteine proteases that are involved in a range of cellular processes. Cathepsins are lysosomal calcium-sensitive proteases that have a key role in cellular protein turnover.

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Cytochrome P450

Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

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Cytokine Receptors

Cytokine receptors are a large family of receptors that are grouped into six categories based upon their three-dimensional structure. The categories are: type I, type II, immunoglobulin superfamily, tumor necrosis factor family, chemokine and TGF-β receptors.

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Hydroxylases

Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), steroid 11-β hydroxylase (E.C. 1.14.15.4), and LTB4 ω-hydroxylase (E.C. 1.14.13.30).

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Kinesin

Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy into mechanical force, typically by hydrolysis of ATP. They act upon microtubules to move vesicles and organelles from the cell centre to the periphery and cause the beating of flagella and cilia.

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Lipoxygenases

Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.

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Matrix Metalloproteases

Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

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Multidrug Transporters

ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.

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PI 3-kinase

PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

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Protein Tyrosine Phosphatases

Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinase and phosphorylase enzymes.

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Voltage-gated Calcium Channels (CaV)

Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression.

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Voltage-gated Sodium (NaV) Channels

Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.

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"2B13" has 1 results in Resources.

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

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