Epigenetics Scientific Review

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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Review excerpt: "While histone deacetylase (HDAC) inhibitors were discovered as early as 1978, other epigenetic proteins and their inhibitors have only recently become the focus of intensive research. Unrestricted access to well-characterized chemical probes has now opened up new areas of biological research and therapeutic possibilities."

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Epigenetics Scientific Review

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