Autophagy Scientific Review

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Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Review excerpt: "Cell homeostasis involves a fine balance between anabolism and catabolism. In cells, the main catabolic pathways are the ubiquitin-proteasome pathway and the autophagy-lysosomal pathway, through which degradation takes place inside lysosomes. Macroautophagy is a highly regulated cellular mechanism for the degradation and recycling of cytoplasmic contents, including proteins, lipids and whole organelles."

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Autophagy Scientific Review

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