Retinoid Receptors Scientific Review
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A summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Compounds available from Tocris are listed.
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.
Review excerpt: "Retinoid signaling can induce cellular differentiation or apoptosis, which is partly relevant in the treatment of cancer. Due to this, there has been a tremendous effort to develop safe and receptor-selective compounds. Structural analysis of various receptors in combination with ATRA, 9-cis-RA or synthetic agonists or antagonists has provided the retinoid field with an unprecedented molecular understanding of the subtle changes necessary to produce the desired receptor response and to confer specific activity."Request copy | Download PDF | View all reviews
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