Stem Cells Scientific Review

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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Review excerpt: "Signaling pathways that control cell proliferation and differentiation are important targets for small molecules in the culture of stem cells. Targeting pathways such as the canonical Wnt, transforming growth factor-β (TGF-β) and retinoic acid signaling pathways can be useful to enhance and maintain the proliferation of stem cells, or to guide stem cell fate toward specific lineages in controlled differentiation."

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Stem Cells Scientific Review

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