Metabotropic Glutamate Receptors Scientific Review

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Glutamate is the major excitatory amino acid transmitter in the brain. This review explains the pharmacology of mGlu receptors and the compounds acting upon them, listing those mGlu compounds available from Tocris.

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Review excerpt: "Glutamate has been shown to be involved in many neuropathologies, such as anxiety, pain, ischemia, Parkinson's disease, epilepsy and schizophrenia. Thus, because of their modulating properties, mGlu receptors are recognized as promising therapeutic targets. It is expected that drugs acting at mGlu receptors will regulate the glutamatergic system without affecting normal synaptic transmission."

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Metabotropic Glutamate Receptors Scientific Review

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