GABA Receptors Scientific Review

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A review of the structure and function of GABA receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Review excerpt: "Despite the overwhelming representation of GPCRs in the human genome, it is the ionotropic receptor for the major inhibitory neurotransmitter GABA that has achieved the most visibility to date. Its serendipitous exploitation within the clinical arena has stimulated a plethora of intriguing insights into the mechanisms by which communication within the nervous system is achieved and the nuances of modulation which provide opportunities for further refinement of pharmacological intervention."

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GABA Receptors Scientific Review

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