MAPK Signaling Scientific Review

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MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer research. This review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Written by Elma Zaganjor and Melanie H. Cobb, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. MAP kinase signaling is integral to the regulation of numerous cellular processes and as a result is an important focus of cancer research. Compounds available from Tocris are listed.

Review excerpt: "The transmission of extracellular signals into intracellular responses is a complex process which often involves the activity of one or more mitogen-activated protein kinases (MAPKs). The activation of a MAPK employs a core three-kinase cascade...upon activation, MAPKs can phosphorylate a variety of intracellular targets including transcription factors, nuclear pore proteins, membrane transporters, cytoskeletal elements, and other protein kinases."

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MAPK Signaling Scientific Review

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