Dopamine Receptors Scientific Review

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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Review excerpt: "It was not until the late 1950's that dopamine was recognized as a neurotransmitter in its own right, but the demonstration of its non-uniform distribution in the brain, distinct from the distribution of noradrenaline, suggested a specific functional role for dopamine. Interest in dopamine was intensified by the realization that dopamine had an important role in the pathogenesis or drug treatment of certain neurological disorders, e.g. Parkinson's disease and schizophrenia. This lead to much research on the sites of action of dopamine and the dopamine receptors."

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Dopamine Receptors Scientific Review

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