Cancer Metabolism

More Information »Genetic alterations and epigenetic modifications of cancer cells result in cellular metabolic pathways that are different in comparison to normal cells. Due to the inherent genetic instability of cancer cells, tumors are heterogeneous with a myriad microenvironments and multiple altered metabolic pathways, which could provide useful cancer therapeutic targets.

Cancer Metabolism Product Areas

Cancer Metabolism Therapeutic Targets

(Taken from Cancer Metabolism, Cancer Research Product Guide Edition 3, 2015)

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Cancer Metabolism

Figure 1: In cancer cells, increased transporter expression facilitates increased uptake of substrates for metabolic pathways including glycolysis, pentose phosphate pathway (PPP), oxidative phosphorylation (OXPHOS) and lipidogenesis. Mutant enzymes and abnormal regulation of these key pathways, drive cellular proliferation and promote cell survival. Furthermore, alterations in pH and the redox balance provide cytoprotective advantages and promote invasion and cell survival (broken arrow = additional intermediate steps not shown).

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Cancer Metabolism

Taken from the Cancer Guide Edition 3

Cancer Metabolism Life Science Poster

Our Cancer Metabolism poster summarizes the main metabolic pathways in cancer cells, and highlights potential targets for cancer therapeutics. Request copy or view PDF today.

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