More Information »Genetic alterations and epigenetic modifications of cancer cells result in cellular metabolic pathways that are different in comparison to normal cells. Due to the inherent genetic instability of cancer cells, tumors are heterogeneous with a myriad microenvironments and multiple altered metabolic pathways, which could provide useful cancer therapeutic targets.
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(Taken from Cancer Metabolism, Cancer Research Product Guide Edition 3, 2015)Enlarge »
Figure 1:In cancer cells, increased transporter expression facilitates increased uptake of substrates for metabolic pathways including glycolysis, pentose phosphate pathway (PPP), oxidative phosphorylation (OXPHOS) and lipidogenesis. Mutant enzymes and abnormal regulation of these key pathways, drive cellular proliferation and promote cell survival. Furthermore, alterations in pH and the redox balance provide cytoprotective advantages and promote invasion and cell survival (broken arrow = additional intermediate steps not shown).
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