Growth Factors and Cytokines

Growth factors are extracellular polypeptides that bind to cell surface receptors and trigger intracellular signaling cascades, resulting in cell proliferation and/or differentiation. Growth factors can be versatile, stimulating growth in a variety of different cell types (for example IGF-1), whilst others are cell-specific (for example erythropoietin acts solely on erythrocytes).

Growth Factors and Cytokines Product Areas

Cytokines are a subtype of growth factors that are produced by hematopoietic and immune cell types, and include interferons and interleukins. They are able to inhibit, as well as stimulate, cell proliferation and differentiation. Cytokines can act in an autocrine, paracrine or endocrine manner and there is little to distinguish them from hormones. Cytokines are the main mediator of the innate and adaptive immune responses.

Growth Factors, Cytokines and Cancer

Growth factors regulate the fundamental cellular process of proliferation and differentiation. Overproduction of growth factors is a common feature of tumor cells, stimulating inappropriate and unregulated proliferation of themselves in an autocrine fashion, and of adjacent cells in a paracrine fashion. Furthermore, activating mutations in growth factor tyrosine kinase receptors, which leads to constitutive receptor activation, are seen in a variety of tumor cell types.

Dysregulation of cytokine signaling is implicated in malignancy, in addition to several other pathophysiological processes including viral infections and autoimmune diseases. Under normal conditions, host-derived cytokines suppress tumor formation by controlling infection, inflammation and immunity. Some tumor cells exploit host-derived cytokines to promote growth, attenuate apoptosis, and facilitate invasion and metastasis.

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

divider line

MAPK Pathway

MAPK Signaling Pathway

The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.