More Information »The cell cycle is the regulatory network that controls the order and timing of cellular proliferation events. It is divided into four stages, G1-S-G2-M. The G1 and G2 stages stand for 'GAP 1' and 'GAP 2' respectively. The S stage stands for 'Synthesis' and is the stage when DNA replication occurs. The M stage stands for 'mitosis', and is when division occurs, halving of the genome.
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Taken from Cell Cycle, Cancer Research Product Guide Edition 3, 2015Enlarge »
Figure 1:At specific points in the cell cycle, DNA damage is detected and repaired. The process is initiated by the DNA damage sensors, ATM and ATR kinase. Checkpoint kinases Chk1 and Chk2 initiate signaling cascades that activate DNA damage checkpoints in G1 and G2. The spindle assembly checkpoint (SAC) delays anaphase of mitosis until all chromosomes are properly aligned on the spindle, preventing aneuploidy. Kinases including aurora kinase B (Aur B), PLK1 and Mps1 are implicated at various control points in the cell cycle.
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May 17 - 19, 2017