VH 032 phenol - linker 2

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Cat.No. 6910 - VH 032 phenol - linker 2 | C30H45N5O5S.2HCl
Description: VH 032 phenol-alkylC6-amine
Chemical Name: (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-((6-aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 660.7
Formula C30H45N5O5S.2HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C)=O)C(C)(C)C)=O)=O)C(OCCCCCCN)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 66.07 100
DMF 66.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 660.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.51 mL 7.57 mL 15.14 mL
5 mM 0.3 mL 1.51 mL 3.03 mL
10 mM 0.15 mL 0.76 mL 1.51 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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References

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Keywords: VH 032 phenol - linker 2, VH 032 phenol - linker 2 supplier, PROTACs, von-Hippel-Lindau, protein, ligand, VHL, E3, ubiquitin, ligase, short, alkyl, linker, conjugate, VH032, targeted, degradation, TPD, building, blocks, Ligands, Plus, Linkers, 6910, Tocris Bioscience

Citations for VH 032 phenol - linker 2

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Literature in this Area

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Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed.