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Thalidomide - linker 14 New
Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker with ethylamine terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 498.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.01 mL||20.04 mL||40.09 mL|
|2.5 mM||0.8 mL||4.01 mL||8.02 mL|
|5 mM||0.4 mL||2 mL||4.01 mL|
|25 mM||0.08 mL||0.4 mL||0.8 mL|
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Keywords: Thalidomide - linker 14, Thalidomide - linker 14 supplier, functionalized, thalidomide, E3, ligase, ligands, cereblon, PEG, linker, conjugate, PROTAC, targeted, protein, degradation, TPD, targeting, 1957235-74-3, Cereblon, Ligands, Plus, Linkers, 6967, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed.