Thalidomide - linker 12

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Cat.No. 6951 - Thalidomide - linker 12 | C25H35N3O10.HCl | CAS No. 2341841-01-6
Description: Thalidomide-PEG5-ethylamine
Chemical Name: 4-((17-Amino-3,6,9,12,15-pentaoxaheptadecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Technical Data

M. Wt 574.02
Formula C25H35N3O10.HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2341841-01-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 57.4 100
DMF 57.4 100

Preparing Stock Solutions

The following data is based on the product molecular weight 574.02. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.71 mL 17.42 mL
5 mM 0.35 mL 1.74 mL 3.48 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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References are publications that support the biological activity of the product.

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Keywords: Thalidomide - linker 12, Thalidomide - linker 12 supplier, functionalized, PROTAC, cereblon, E3, ubiquitin, ligase, PEG, linker, conjugate, polyethene, glycol, targeted, protein, degradation, TPD, Cereblon, Ligands, Plus, Linkers, 6951, Tocris Bioscience

Citations for Thalidomide - linker 12

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia