Spermidine trihydrochloride

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Cat.No. 0959 - Spermidine trihydrochloride | C7H19N3.3HCl | CAS No. 334-50-9
Description: Agonist at polyamine site
Chemical Name: N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride
Datasheet
Citations
Literature

Biological Activity

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801. Activates autophagy.

Technical Data

M. Wt 254.63
Formula C7H19N3.3HCl
Storage Desiccate at +4°C
CAS Number 334-50-9
PubChem ID 9539
InChI Key LCNBIHVSOPXFMR-UHFFFAOYSA-N
Smiles Cl.Cl.Cl.NCCCCNCCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 254.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.64 mL 39.27 mL
5 mM 0.79 mL 3.93 mL 7.85 mL
10 mM 0.39 mL 1.96 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kishi et al (1998) Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res. 793 311 PMID: 9630697

Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163 PMID: 8358608

Williams et al (1989) Effects of polyamines on the binding of [3H]-MK801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol.Pharmacol. 36 375 PMID: 2554112

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 8529316


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Keywords: Spermidine trihydrochloride, supplier, Agonist, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, NMDA, Receptors, Tocris Bioscience

Citations for Spermidine trihydrochloride

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