Discontinued Product

Semax (Cat. No. 7712) has been withdrawn from sale for commercial reasons.
Description: Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for Semax

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) (4-10). It increases hippocampal BDNF and TrkB expression and levels in vivo. Semax regulates cortical nitric oxide (NO) and lipid peroxidation and is neuroprotective in a rat model of global ischemia. Semax sequesters copper ions and interacts directly with Aβ:Cu2+ oligomers leading to reduced amyloid β protein (Aβ) aggregation and fibrillogenesis. Semax increases viability of d-SH-SY5Y cells pre-incubated with Aβ1-42 oligomers.

Technical Data for Semax

M. Wt 813.93
Formula C37H51N9O10S
Sequence MEHFPGP
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 80714-61-0
PubChem ID 9811102
Smiles O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(NCC(N4[C@@H](CCC4)C(O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: Semax, Semax supplier, peptides, analogs, adrenocorticotropic, hormone, hippocampal, BDNF, trkB, neuroprotective, global, ischemia, amyloid, beta, Aβ, ABeta, aggregation, inhibits, fibrillogenesis, Alzheimers, Amyloid, Beta, Peptides, Other, RTKs, 7712, Tocris Bioscience

Citations for Semax

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Currently there are no citations for Semax.

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Literature in this Area

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Alzheimer's Disease Poster

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