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Discontinued ProductSDZ 221-653 (Cat. No. 1252) has been withdrawn from sale for commercial reasons.
Biological Activity for SDZ 221-653
Competitive NMDA antagonist (pKi = 6.3); less active enantiomer of SDZ 220-581 (cat.no. 1250).
Sold with the permission of Novartis Pharma AG.
Technical Data for SDZ 221-653
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SDZ 221-653
References for SDZ 221-653
References are publications that support the biological activity of the product.
Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 35 643 PMID: 8887974
Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 35 655 PMID: 8887975
Keywords: SDZ 221-653, SDZ 221-653 supplier, NMDA, Receptors, 1252, Tocris Bioscience
Citations for SDZ 221-653
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Currently there are no citations for SDZ 221-653.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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- Nuclear-Cytoplasmic Transport Interference
- Stem Cells
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Huntington's Disease PosterUpdated
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
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