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Discontinued Product
(S)-α-Methyl-3-carboxyphenylalanine (Cat. No. 0857) has been withdrawn from sale for commercial reasons.
Description: Group III mGlu antagonist
Biological Activity for (S)-α-Methyl-3-carboxyphenylalanine
Potent, highly selective antagonist of L-AP4- induced depression of forskolin-stimulated cAMP production in rat brain cerebrocortical slices; 100 fold less potent versus L-CCG-I -induced depression.
Technical Data for (S)-α-Methyl-3-carboxyphenylalanine
| M. Wt | 223.23 |
| Storage | Store at RT |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (S)-α-Methyl-3-carboxyphenylalanine
Certificate of Analysis is currently unavailable on-line.
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References for (S)-α-Methyl-3-carboxyphenylalanine
References are publications that support the biological activity of the product.
Bruno et al (1996) Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Eur.J.Pharmacol. 310 61 PMID: 8880068
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
Watkins and Collingridge (1994) Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. TiPS 15 333 PMID: 7992387
Kemp et al (1994) Antagonist effects of 3-carboxy derivatives of phenylglycine and phenylalanine mGluR ligands on cortical adenylyl cyclase activity. Br.J.Pharmacol. 113 147P
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Keywords: (S)-a-Methyl-3-carboxyphenylalanine, (S)-a-Methyl-3-carboxyphenylalanine supplier, Glutamate, (Metabotropic), Group, III, Receptors, 0857, Tocris Bioscience
Citations for (S)-α-Methyl-3-carboxyphenylalanine
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Currently there are no citations for (S)-α-Methyl-3-carboxyphenylalanine.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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