(RS)-1-Amino-3-(phosphonomethylene)cyclobutanecarboxylic acid

Discontinued Product

Unfortunately (RS)-1-Amino-3-(phosphonomethylene)cyclobutanecarboxylic acid (Cat. No. 0335) has been withdrawn from sale for commercial reasons.
Cat.No. 0335 - (RS)-1-Amino-3-(phosphonomethylene)cyclobutanecarboxylic acid | CAS No. 140480-88-2
Description: Group III mGlu agonist. Analogue of L-AP4

Biological Activity

L-AP4 analogue, active at group III mGlu receptors.

Technical Data

M. Wt 207.13
Storage Store at RT
CAS Number 140480-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 207.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.14 mL 48.28 mL
5 mM 0.97 mL 4.83 mL 9.66 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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Safety Datasheet


References are publications that support the products' biological activity.

Allan et al (1990) Synthesis and activity of a potent NMDA agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids. J.Med.Chem. 33 2905 PMID: 2145435

Peterson et al (1992) Activity of the conformationally rigid 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid on evoked responses in the perforant pathway of the rat hippocampus. Brain Res. 571 162 PMID: 1611490

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Keywords: (RS)-1-Amino-3-(phosphonomethylene)cyclobutanecarboxylic acid, supplier, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

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