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Cat.No. 4412 - Psilocin | C12H16N2O | CAS No. 520-53-6
Description: Non-selective serotonin receptor agonist
Chemical Name: 4-Hydroxy-N,N-dimethyltryptamine
Purity: ≥99%

Biological Activity

Non-selective serotonin receptor agonist. Active metabolite of psilocybin; hallucinogen.

Technical Data

M. Wt 204.27
Formula C12H16N2O
Storage Store at -20°C
Purity ≥99%
CAS Number 520-53-6
PubChem ID 4980
Smiles OC1=C2C(NC=C2CCN(C)C)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 204.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.9 mL 24.48 mL 48.95 mL
5 mM 0.98 mL 4.9 mL 9.79 mL
10 mM 0.49 mL 2.45 mL 4.9 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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Product Datasheets

Safety Datasheet


References are publications that support the biological activity of the product.

Merck Index 12 4629

Almaula et al (1996) Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the sa Mol.Pharmacol. 50 34 PMID: 8700116

Lee and Roth (2012) Hallucinogen actions on human brain revealed. Proc.Natl.Acad.Sci.USA 109 1820 PMID: 22308478

If you know of a relevant reference for Psilocin, please let us know.

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Keywords: Psilocin, Psilocin supplier, hallucinogenics, serotonin, serotonergics, 5-ht, receptors, nonselective, agonists, Non-selective, 5-HT, 4412, Tocris Bioscience

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Literature in this Area

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GPCR Product Listing

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.


Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.