OLT 1177

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Cat.No. 6902 - OLT 1177 | C4H7NO2S | CAS No. 54863-37-5
Description: NLRP3 inflammasome inhibitor; disrupts inflammasome formation
Chemical Name: 3-(Methylsulfonyl)propanenitrile
Purity: ≥98%
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1β secretion in human and mouse macrophages in vitro, without affecting TNFα levels. Reduces LPS-induced inflammation in vivo. Also reduces joint swelling and markers of inflammation in synovial fluid in a mouse model of acute arthritis. Displays cardioprotective effects in a mouse model of cardiac ischemic reperfusion injury.

Technical Data

M. Wt 133.17
Formula C4H7NO2S
Storage Store at -20°C
Purity ≥98%
CAS Number 54863-37-5
PubChem ID 12714644
InChI Key LQFRYKBDZNPJSW-UHFFFAOYSA-N
Smiles C[S](=O)(=O)CCC#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.32 100
ethanol 2.66 20

Preparing Stock Solutions

The following data is based on the product molecular weight 133.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.51 mL 37.55 mL 75.09 mL
5 mM 1.5 mL 7.51 mL 15.02 mL
10 mM 0.75 mL 3.75 mL 7.51 mL
50 mM 0.15 mL 0.75 mL 1.5 mL

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References

References are publications that support the biological activity of the product.

Marchetti et al (2018) OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc.Natl.Acad.Sci.USA. 115 E1530 PMID: 29378952

Marchetti et al (2018) NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis. Arthritis Res.Ther. 20 169 PMID: 30075804

Toldo et al (2019) The NLRP3 inflammasome inhibitor, OLT1177 (Dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse. J.Cardiovasc.Pharmacol. 73 215 PMID: 30747785


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