Neurosensor 521

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Cat.No. 5905 - Neurosensor 521 | C21H21NO4 | CAS No. 1428730-05-5
Description: Selective noradrenalin and dopamine fluorescent indicator
Alternative Names: NS521
Chemical Name: 7-(Diethylamino)-4-(4-methoxyphenyl)-2-oxo-2H-1-benzopyran-3-carboxaldehyde
Purity: ≥98% (HPLC)

Biological Activity

Selective noradrenalin and dopamine fluorescent indicator. Exhibits selectivity over adrenalin, glycine and glutamate. Enables visualization of noradrenalin and dopamine in fixed and live cells. Excitation wavelength 488 nm, emission 521 nm.

Technical Data

M. Wt 351.4
Formula C21H21NO4
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 1428730-05-5
PubChem ID 86272181
Smiles O=C1OC2=CC(N(CC)CC)=CC=C2C(C3=CC=C(C=C3)OC)=C1C=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.57 50

Preparing Stock Solutions

The following data is based on the product molecular weight 351.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.69 mL 28.46 mL 56.92 mL
2.5 mM 1.14 mL 5.69 mL 11.38 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
25 mM 0.11 mL 0.57 mL 1.14 mL

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References are publications that support the biological activity of the product.

Hettie et al (2013) Selective catecholamine recognition with NeuroSensor 521: a fluorescent sensor for the visualization of NE in fixed and live cells. ACS Chem.Neurosci. 4 918 PMID: 23527575

Yin et al (2017) A two-input fluorescent logic gate for glutamate and zinc. ACS.Chem.Neurosci. 8 1159 PMID: 28257176

If you know of a relevant reference for Neurosensor 521, please let us know.

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