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Cat.No. 6183 - Nanchangmycin | C47H77NaO14 | CAS No. 65101-87-3
Description: Antiviral; active against Zika, West Nile and dengue viruses
Chemical Name: (2S,4R,6E,8S)-8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-Hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5-oxo-6-nonenoic acid sodium salt

Biological Activity

Antiviral. Inhibits Zika virus entry in a range of cell types including primary placental fibroblast cells, HUVECs and UtMECs (IC50 values are 0.1, 0.4 and 0.97 μM in U2OS, HBMECs and Jeg-3 cells respectively). Also inhibits cellular uptake of West Nile, dengue, sindbis and chikungunya viruses.

Technical Data

M. Wt 889.1
Formula C47H77NaO14
Storage Store at -20°C
CAS Number 65101-87-3
PubChem ID 46930988
Smiles [H][C@]1([C@]2(O[C@@](CO)([C@@H](C[C@@H]2C)C)O)[H])C[C@@H]([C@@]3(O[C@](C[C@@H]([C@H]3C)O[C@@]4(CC[C@@H]([C@H](O4)C)OC)[H])([C@@]5(CC[C@@]6(O5)C[C@@H]([C@H]([C@](O6)([C@H](/C=C(C([C@@H](C[C@@H](C(O[Na])=O)C)C)=O)\C)C)[H])C)O)C)[H])O1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 88.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 889.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.12 mL 5.62 mL 11.25 mL
5 mM 0.22 mL 1.12 mL 2.25 mL
10 mM 0.11 mL 0.56 mL 1.12 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Rausch et al (2017) Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 18 804 PMID: 28099856

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Keywords: Nanchangmycin, supplier, Inhibitors, Inhibits, Zika, virus, antiviral, cellular, uptake, west, nile, dengue, sindbis, chikungunya, Antivirals, Antivirals, Tocris Bioscience

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