Nanchangmycin

Discontinued Product

Nanchangmycin (Cat. No. 6183) has been withdrawn from sale for commercial reasons.
Cat.No. 6183 - Nanchangmycin | C47H77NaO14 | CAS No. 65101-87-3
Description: Antiviral; active against Zika, West Nile and dengue viruses
Chemical Name: (2S,4R,6E,8S)-8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-Hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5-oxo-6-nonenoic acid sodium salt
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Antiviral. Inhibits Zika virus entry in a range of cell types including primary placental fibroblast cells, HUVECs and UtMECs (IC50 values are 0.1, 0.4 and 0.97 μM in U2OS, HBMECs and Jeg-3 cells respectively). Also inhibits cellular uptake of West Nile, dengue, sindbis and chikungunya viruses.

Technical Data

M. Wt 889.1
Formula C47H77NaO14
Storage Store at -20°C
CAS Number 65101-87-3
PubChem ID 46930988
InChI Key XMAIRYYXDCNFKP-DYTQFKGPSA-M
Smiles [H][C@]1([C@]2(O[C@@](CO)([C@@H](C[C@@H]2C)C)O)[H])C[C@@H]([C@@]3(O[C@](C[C@@H]([C@H]3C)O[C@@]4(CC[C@@H]([C@H](O4)C)OC)[H])([C@@]5(CC[C@@]6(O5)C[C@@H]([C@H]([C@](O6)([C@H](/C=C(C([C@@H](C[C@@H](C(O[Na])=O)C)C)=O)\C)C)[H])C)O)C)[H])O1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Rausch et al (2017) Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 18 804 PMID: 28099856

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