Monensin sodium salt
Sodium ionophore. Neutralizes acidic intracellular compartments. Disrupts Golgi apparatus structure and inhibits vesicular transport in eukaryotic cells. Induces apoptosis in prostate cancer cells. Antiprotozoal, antibacterial and antifungal agent.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 692.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.44 mL||7.22 mL||14.43 mL|
|5 mM||0.29 mL||1.44 mL||2.89 mL|
|10 mM||0.14 mL||0.72 mL||1.44 mL|
|50 mM||0.03 mL||0.14 mL||0.29 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Mollenhauer et al (1990) Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim.Biophys.Acta 1031 225 PMID: 2160275
Łowicki and Huczyński (2013) Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements. Biomed.Res.Int 2013 PMID: 23509771
Ketola et al (2010) Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells. Mol.Cancer Ther. 9 3175 PMID: 21159605
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Keywords: ionophores ion channels modulators antibacterial antiprotozoal antifungal induces apoptosis Ionophores
Citations for Monensin sodium salt
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Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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