Monensin sodium salt

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Cat.No. 5223 - Monensin sodium salt | C36H61NaO11 | CAS No. 22373-78-0
Description: Sodium ionophore; antibacterial agent
Chemical Name: 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-Dioxaspiro[4.5]decane-7-butyric acid sodium salt
Datasheet
Citations
Literature

Biological Activity

Sodium ionophore. Neutralizes acidic intracellular compartments. Disrupts Golgi apparatus structure and inhibits vesicular transport in eukaryotic cells. Induces apoptosis in prostate cancer cells. Antiprotozoal, antibacterial and antifungal agent.

Technical Data

M. Wt 692.85
Formula C36H61NaO11
Storage Store at +4°C
CAS Number 22373-78-0
PubChem ID 23667299
InChI Key XOIQMTLWECTKJL-FBZUZRIGSA-M
Smiles C[C@@H]([C@@H](OC)[C@@H](C(O[Na])=O)C)[C@]1([H])[C@H](C)[C@@H](O)C[C@]2(CC[C@]([C@]3([H])O[C@@]([C@@]4([H])[C@@H](C)C[C@@]([C@]5([H])[C@@H](C)C[C@@H](C)[C@@](CO)(O)O5)([H])O4)(CC)CC3)(C)O2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 69.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 692.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.22 mL 14.43 mL
5 mM 0.29 mL 1.44 mL 2.89 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Mollenhauer et al (1990) Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim.Biophys.Acta 1031 225 PMID: 2160275

Łowicki and Huczyński (2013) Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements. Biomed.Res.Int 2013 PMID: 23509771

Ketola et al (2010) Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells. Mol.Cancer Ther. 9 3175 PMID: 21159605


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Keywords: ionophores ion channels modulators antibacterial antiprotozoal antifungal induces apoptosis Ionophores

Citations for Monensin sodium salt

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Monensin sodium salt

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