Monensin sodium salt

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Cat.No. 5223 - Monensin sodium salt | C36H61NaO11 | CAS No. 22373-78-0
Description: Sodium ionophore; antibacterial agent
Chemical Name: 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-Dioxaspiro[4.5]decane-7-butyric acid sodium salt
Citations (1)
Literature (1)

Biological Activity

Sodium ionophore. Neutralizes acidic intracellular compartments. Disrupts Golgi apparatus structure and inhibits vesicular transport in eukaryotic cells. Induces apoptosis in prostate cancer cells. Antiprotozoal, antibacterial and antifungal agent.

Technical Data

M. Wt 692.85
Formula C36H61NaO11
Storage Store at +4°C
CAS Number 22373-78-0
PubChem ID 23667299
Smiles C[C@@H]([C@@H](OC)[C@@H](C(O[Na])=O)C)[C@]1([H])[C@H](C)[C@@H](O)C[C@]2(CC[C@]([C@]3([H])O[C@@]([C@@]4([H])[C@@H](C)C[C@@]([C@]5([H])[C@@H](C)C[C@@H](C)[C@@](CO)(O)O5)([H])O4)(CC)CC3)(C)O2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 69.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 692.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.22 mL 14.43 mL
5 mM 0.29 mL 1.44 mL 2.89 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Mollenhauer et al (1990) Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim.Biophys.Acta 1031 225 PMID: 2160275

Łowicki and Huczyński (2013) Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements. Biomed.Res.Int 2013 PMID: 23509771

Ketola et al (2010) Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells. Mol.Cancer Ther. 9 3175 PMID: 21159605

If you know of a relevant reference for Monensin sodium salt, please let us know.

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Keywords: Monensin sodium salt, Monensin sodium salt supplier, ionophores, ion, channels, modulators, antibacterial, antiprotozoal, antifungal, induces, apoptosis, Ionophores, Biochemicals, and, Molecular, Biology, 5223, Tocris Bioscience

1 Citation for Monensin sodium salt

Citations are publications that use Tocris products. Selected citations for Monensin sodium salt include:

Daynac et al (2018) Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis. Nat Commun 9 2862 PMID: 30131568

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels