Monensin sodium salt
Sodium ionophore. Neutralizes acidic intracellular compartments. Disrupts Golgi apparatus structure and inhibits vesicular transport in eukaryotic cells. Induces apoptosis in prostate cancer cells. Antiprotozoal, antibacterial and antifungal agent.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 692.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.44 mL||7.22 mL||14.43 mL|
|5 mM||0.29 mL||1.44 mL||2.89 mL|
|10 mM||0.14 mL||0.72 mL||1.44 mL|
|50 mM||0.03 mL||0.14 mL||0.29 mL|
References are publications that support the products' biological activity.
Mollenhauer et al (1990) Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim.Biophys.Acta 1031 225 PMID: 2160275
Łowicki and Huczyński (2013) Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements. Biomed.Res.Int 2013 PMID: 23509771
Ketola et al (2010) Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells. Mol.Cancer Ther. 9 3175 PMID: 21159605
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Keywords: Monensin sodium salt, supplier, ionophores, ion, channels, modulators, antibacterial, antiprotozoal, antifungal, induces, apoptosis, Ionophores, Biochemicals, and, Molecular, Biology, Ionophores, Tocris Bioscience
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