JHU 37160

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
Chemical Name: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for JHU 37160

JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 0.2 nM and 18.5 nM for hM4Di and hM3Dq in vitro, respectively). Displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21 (Cat. No. 5548). Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. Brain penetrant in mice, rats and non-human primates.

Compound Libraries for JHU 37160

JHU 37160 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JHU 37160

M. Wt 358.85
Formula C19H20ClFN4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 2369979-68-8
PubChem ID 139033723
Smiles CCN1CCN(C2=NC3=CC(Cl)=CC=C3NC4=C(C=CC=C24)F)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JHU 37160

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.94 50

Preparing Stock Solutions for JHU 37160

The following data is based on the product molecular weight 358.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.57 mL 27.87 mL 55.73 mL
2.5 mM 1.11 mL 5.57 mL 11.15 mL
5 mM 0.56 mL 2.79 mL 5.57 mL
25 mM 0.11 mL 0.56 mL 1.11 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for JHU 37160

References are publications that support the biological activity of the product.

Bonaventura et al (2019) High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat.Commun. 10 4627 PMID: 31604917

If you know of a relevant reference for JHU 37160, please let us know.

View Related Products by Target

Keywords: JHU 37160, JHU 37160 supplier, JHU37160, DREADD, agonist, agonists, activator, activators, acutator, muscarinic, hM3Dq, hM4Di, brain, penetrant, DREADDs, 7198, Tocris Bioscience

Citations for JHU 37160

Citations are publications that use Tocris products.

Currently there are no citations for JHU 37160. Do you know of a great paper that uses JHU 37160 from Tocris? Please let us know.

Reviews for JHU 37160

There are currently no reviews for this product. Be the first to review JHU 37160 and earn rewards!

Have you used JHU 37160?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Chemogenetics Research Bulletin

Chemogenetics Research Bulletin

Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.

Allosteric GPCR Pharmacology Poster

Allosteric GPCR Pharmacology Poster

G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.

GPCR Efficacy and Biased Agonism Poster

GPCR Efficacy and Biased Agonism Poster

GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.