Ep23, 5'-DY647

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Cat.No. 6102 - Ep23, 5'-DY647 | C218H259F13N66O132P20
Description: High affinity fluorescently tagged aptamer for EpCam
Protocols (1)
Literature (3)

Biological Activity

High affinity fluorescently tagged aptamer for EpCam (Kd = 39.42 nM in HT29 cells). Efficiently internalized upon binding to EpCAM. Exhibits rapid penetration of tumorspheres in vitro, as well as superior penetration, accumulation and retention in tumor xenografts in vivo than an antibody to the same target.

For optimal binding aptamers require refolding into their tertiary structure prior to use. Please refer to the protocol for information regarding refolding and aptamer use in unfixed cell imaging and flow cytometry.

Licensing Information

Sold under license from the patent holder, Deakin University, Australia.

Application of Ep23, 5'-DY647 in Immunocytochemistry

Application of Ep23, 5'-DY647 in Immunocytochemistry

Aptamer applied at 100 nM concentration to HT29 cells. Magnification 40x.

Image kindly provided by Birte Aggeler, Bio-Techne.

Technical Data

Aptamer type (DNA/RNA) RNA
Number of Bases 19
Sequence Modifications 2-fluoropyrimidines, 3'-inverted deoxythymidine cap, 5'-fluorescent DY647 tag
M. Wt 6782.21
Formula C218H259F13N66O132P20
Storage Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


Please refer to these solubility guidelines for Ep23, 5'-DY647 (Cat. No. 6102).


References are publications that support the biological activity of the product.

Shigdar et al (2011) RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci. 102 991 PMID: 21281402

Shigdar et al (2013) The use of sensitive chemical antibodies for diagnosis: detection of low levels of EpCAM in breast cancer. PLoS One. 8 e57613 PMID: 23460885

Xiang et al (2015) Superior performance of aptamer in tumor penetration over antibody: implication of aptamer-based theranostics in solid tumors. Theranostics. 5 1083 PMID: 26199647

If you know of a relevant reference for Ep23, 5'-DY647, please let us know.

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Citations for Ep23, 5'-DY647

Citations are publications that use Tocris products.

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Protocols for Ep23, 5'-DY647

The following protocol features additional information for the use of Ep23, 5'-DY647 (Cat. No. 6102).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.