D15
Discontinued Product
D15 (Cat. No. 2334) has been withdrawn from sale for commercial reasons.
Biological Activity
Endocytosis inhibitor that blocks the interaction of dynamin with amphiphysin 1 and 2. Impairs AMPA receptor cycling and blocks DHPG-induced long term depression (LTD).
Technical Data
| M. Wt | 1566.78 |
| Formula | C69H111N23O19 |
| Sequence | PPPQVPSRPNRAPPG |
| Storage | Desiccate at -20°C |
| CAS Number | 251939-41-0 |
| PubChem ID | 56972197 |
| InChI Key | CMEJFHBXHREXBP-AVAZHIDJSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Lüscher et al (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24 649 PMID: 10595516
Xiao et al (2001) Metabolic glutamate receptor activation causes a rapid redistribution of AMPA receptors. Neuropharmacology 41 664 PMID: 11640920
Wigge and McMahon (1998) The amphiphysin family of proteins and their role in endocytosis at the synapse. Trends Neursci. 21 339
View Related Products by Target
Keywords: D15, D15 supplier, Endocytosis, blockers, impairs, AMPA, receptor, cycling, dynamin, amphiphysin, 1, 2, Receptors, Translocation,, Exocytosis, &, 2334, Tocris Bioscience
1 Citation for D15
Citations are publications that use Tocris products. Selected citations for D15 include:
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
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- Receptor Signaling
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