D15

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Cat.No. 2334 - D15 | Pro-Pro-Pro-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-Pro-Gly | CAS No. 251939-41-0
Description: Endocytosis blocker
Datasheet
Citations
Literature

Biological Activity

Endocytosis inhibitor that blocks the interaction of dynamin with amphiphysin 1 and 2. Impairs AMPA receptor cycling and blocks DHPG-induced long term depression (LTD).

Technical Data

M. Wt 1566.78
Formula C69H111N23O19
Sequence PPPQVPSRPNRAPPG
Storage Desiccate at -20°C
CAS Number 251939-41-0
PubChem ID 56972197
InChI Key CMEJFHBXHREXBP-AVAZHIDJSA-N
Smiles [H]N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1566.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.19 mL 6.38 mL
5 mM 0.13 mL 0.64 mL 1.28 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lüscher et al (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24 649 PMID: 10595516

Xiao et al (2001) Metabolic glutamate receptor activation causes a rapid redistribution of AMPA receptors. Neuropharmacology 41 664 PMID: 11640920

Wigge and McMahon (1998) The amphiphysin family of proteins and their role in endocytosis at the synapse. Trends Neursci. 21 339 PMID:


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Keywords: D15, supplier, Endocytosis, blockers, impairs, AMPA, receptor, cycling, dynamin, amphiphysin, 1, 2, AMPA, Receptors, Translocation,, Exocytosis, &, Endocytosis, Translocation,, Exocytosis, &, Endocytosis, Tocris Bioscience

Citations for D15

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