Endocytosis inhibitor that blocks the interaction of dynamin with amphiphysin 1 and 2. Impairs AMPA receptor cycling and blocks DHPG-induced long term depression (LTD).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1566.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.64 mL||3.19 mL||6.38 mL|
|5 mM||0.13 mL||0.64 mL||1.28 mL|
|10 mM||0.06 mL||0.32 mL||0.64 mL|
|50 mM||0.01 mL||0.06 mL||0.13 mL|
References are publications that support the products' biological activity.
Lüscher et al (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24 649 PMID: 10595516
Xiao et al (2001) Metabolic glutamate receptor activation causes a rapid redistribution of AMPA receptors. Neuropharmacology 41 664 PMID: 11640920
If you know of a relevant reference for D15, please let us know.
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Keywords: D15, supplier, Endocytosis, blockers, impairs, AMPA, receptor, cycling, dynamin, amphiphysin, 1, 2, AMPA, Receptors, Translocation,, Exocytosis, &, Endocytosis, Translocation,, Exocytosis, &, Endocytosis, Tocris Bioscience
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