CMP 98

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Cat.No. 6417 - CMP 98 | C58H82N8O14S2
Description: Negative Control for CM 11
Chemical Name: N1,N20-bis((S)-1-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Negative Control for CM 11 (Cat. No. 6416). Exhibits no effect on VHL degradation.

Licensing Information

Sold under licence from the University of Dundee

Technical Data

M. Wt 1179.46
Formula C58H82N8O14S2
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles CC1=C(C2=CC=C(CNC([C@@H]3C[C@H](O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@H](O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 117.95 100
DMSO 117.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 1179.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.85 mL 4.24 mL 8.48 mL
5 mM 0.17 mL 0.85 mL 1.7 mL
10 mM 0.08 mL 0.42 mL 0.85 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Maniaci et al (2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Commun. 8 830 PMID: 29018234


If you know of a relevant reference for CMP 98, please let us know.

Keywords: CMP 98, CMP 98 supplier, CMP98, PROTAC, proteolysis, targeting, chimera, CM11, negative, control, VHL, E3, ligase, Ubiquitin, Ligases, PROTACs, 6417, Tocris Bioscience

Citations for CMP 98

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Literature in this Area

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