CMP 98

Discontinued Product

CMP 98 (Cat. No. 6417) has been withdrawn from sale for commercial reasons.
Description: Negative Control for CM 11 (Cat. No. 6416)
Chemical Name: N1,N20-bis((S)-1-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for CMP 98

CMP 98 is a negative Control for CM 11 (Cat. No. 6416). Exhibits no effect on VHL degradation.

Licensing Information

Sold under licence from the University of Dundee

Technical Data for CMP 98

M. Wt 1179.46
Formula C58H82N8O14S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2244684-50-0
PubChem ID 134160243
Smiles CC1=C(C2=CC=C(CNC([C@@H]3C[C@H](O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@H](O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CMP 98

References are publications that support the biological activity of the product.

Maniaci et al (2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Commun. 8 830 PMID: 29018234

Keywords: CMP 98, CMP 98 supplier, CMP98, PROTAC, PROTACs, proteolysis, targeting, chimera, CM11degraders, negative, controls, VHL, E3, ligase, Ubiquitin, Ligases, Active, Degraders, 6417, Tocris Bioscience

Citations for CMP 98

Citations are publications that use Tocris products.

Currently there are no citations for CMP 98.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Targeted Protein Degradation Research Product Guide

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This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
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  • Ubiquitin-Proteasome System Proteins
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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia