CD133-B19, 5'-DY647

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Cat.No. 6104 - CD133-B19, 5'-DY647 | C221H263F10N73O131P20
Description: High affinity fluorescently tagged aptamer for CD133 (extracellular domain epitope)
Protocols (1)
Literature (1)

Biological Activity for CD133-B19, 5'-DY647

CD133-B19, 5'-DY647 is a high affinity fluorescently tagged aptamer for CD133 (extracellular domaine epitope) (Kd values are 52.3 and 145.1 nM in Hep3B and HT29 cells, respectively). Efficiently internalized upon binding to CD133. Exhibits superior penetration of tumorspheres compared with an antibody to the same target.

For optimal binding aptamers require refolding into their tertiary structure prior to use. Please refer to the protocol for information regarding refolding and aptamer use in unfixed cell imaging and flow cytometry.

Licensing Information

Sold under license from the patent holder, Deakin University.

Technical Data for CD133-B19, 5'-DY647

Aptamer type (DNA/RNA) RNA
Number of Bases 19
Sequence Modifications 2-fluoropyrimidines, 3'-inverted deoxythymidine cap, 5'-fluorescent DY647 tag
M. Wt 6847.32
Formula C221H263F10N73O131P20
Storage Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CD133-B19, 5'-DY647

Please refer to these solubility guidelines for CD133-B19, 5'-DY647 (Cat. No. 6104).

Product Datasheets for CD133-B19, 5'-DY647

References for CD133-B19, 5'-DY647

References are publications that support the biological activity of the product.

Shigdar et al (2013) RNA aptamers targeting cancer stem cell marker CD133. Cancer Lett. 330 84 PMID: 23196060

If you know of a relevant reference for CD133-B19, 5'-DY647, please let us know.

Keywords: CD133-B19, 5'-DY647, CD133-B19, 5'-DY647 supplier, CD133-B19-5-DY647, Aptamers, CD133, extracellular, domain, epitope, fluorescent, high, affinity, Prominin-1, Cancer, Stem, Cells, Fluorescent, Cell, Surface, Markers, 6104, Tocris Bioscience

Citations for CD133-B19, 5'-DY647

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Protocols for CD133-B19, 5'-DY647

The following protocol features additional information for the use of CD133-B19, 5'-DY647 (Cat. No. 6104).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Fluorescent Probes and Dyes

Fluorescent Probes and Dyes Research Product Guide

This product guide provides a comprehensive list and background to the use of Fluorescent Probes and Dyes

  • Fluorescent Dyes
  • Dyes for Flow Cytometry
  • Fluorescent Probes
  • Anti-fade Reagents
  • Bioluminescent Substrates
  • Fluorogenic Dyes for Light-Up Aptamers
  • Fluorescent Probes for Imaging Bacteria
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals