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High affinity fluorescently tagged aptamer for CD133 (extracellular domaine epitope) (Kd values are 52.3 and 145.1 nM in Hep3B and HT29 cells, respectively). Efficiently internalized upon binding to CD133. Exhibits superior penetration of tumorspheres compared with an antibody to the same target.
For optimal binding aptamers require refolding into their tertiary structure prior to use. Please refer to the protocol for information regarding refolding and aptamer use in unfixed cell imaging and flow cytometry.
Sold under license from the patent holder, Deakin University.
|Aptamer type (DNA/RNA)||RNA|
|Number of Bases||19|
|Sequence Modifications||2-fluoropyrimidines, 3'-inverted deoxythymidine cap, 5'-fluorescent DY647 tag|
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Please refer to these solubility guidelines for CD133-B19, 5'-DY647 (Cat. No. 6104).
References are publications that support the biological activity of the product.
Shigdar et al (2013) RNA aptamers targeting cancer stem cell marker CD133. Cancer Lett. 330 84 PMID: 23196060
If you know of a relevant reference for CD133-B19, 5'-DY647, please let us know.
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Keywords: CD133-B19, 5'-DY647, CD133-B19, 5'-DY647 supplier, CD133-B19-5-DY647, Aptamers, CD133, extracellular, domain, epitope, fluorescent, high, affinity, Prominin-1, Cancer, Stem, Cells, Fluorescent, Cell, Surface, Markers, 6104, Tocris Bioscience
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Protocols for CD133-B19, 5'-DY647
The following protocol features additional information for the use of CD133-B19, 5'-DY647 (Cat. No. 6104).
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