Camostat mesylate

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Cat.No. 3193 - Camostat mesylate | C20H22N4O5.CH3SO3H | CAS No. 59721-29-8
Description: Orally active protease inhibitor; inhibits entry of SARS-Cov-2 into lung cells
Chemical Name: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (1)

Biological Activity

Orally active protease inhibitor. Inhibits trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration. Also inhibits transmembrane serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (COVID-19) into lung cells in vitro.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries

Camostat mesylate is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 494.52
Formula C20H22N4O5.CH3SO3H
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 59721-29-8
PubChem ID 43071
InChI Key FSEKIHNIDBATFG-UHFFFAOYSA-N
Smiles O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.73 50
DMSO 49.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 494.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.11 mL 20.22 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Horiuchi et al (1990) Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 252 320 PMID: 1688943

Ishikura et al (2007) The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 80 1999 PMID: 17433371

Hoffmann et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell 181 271 PMID: 32142651


If you know of a relevant reference for Camostat mesylate, please let us know.

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Literature in this Area

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New Product Guide [Spring/Summer 2019]

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