[Ala2,8,9,11,19,22,24,25,27,28]-VIP

Discontinued Product

Unfortunately [Ala2,8,9,11,19,22,24,25,27,28]-VIP (Cat. No. 3095) has been withdrawn from sale for commercial reasons.
Cat.No. 3095 - [Ala2,8,9,11,19,22,24,25,27,28]-VIP | His-Ala-Asp-Ala-Val-Phe-Thr-Ala-Ala-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Ala-Lys-Lys-Ala-Leu-Ala-Ala-Ile-Ala-Ala-NH2 | CAS No. 866552-34-3
Description: Highly selective VPAC1 agonist
Datasheet
Citations
Literature

Biological Activity

Highly selective agonist for the VPAC1 receptor (IC50 values are ~ 11.5-13.2 and > 30000 nM for VPAC1 and VPAC2 receptors respectively).

Technical Data

M. Wt 2928.49
Formula C131H219N41O33S
Sequence HADAVFTAAYARLRKQMAAKKALAAIAA

(Modifications: Ala-28 = C-terminal amide)

Storage Store at -20°C
CAS Number 866552-34-3
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 2928.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.34 mL 1.71 mL 3.41 mL
5 mM 0.07 mL 0.34 mL 0.68 mL
10 mM 0.03 mL 0.17 mL 0.34 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Igarashi et al (2005) Development of simplified vasoactive intestinal peptide analogs with receptor selectivity and stability for human vasoactive intestinal peptide/pituitary adenylate cyclase-activating polypeptide receptors. J.Pharmacol.Exp.Ther. 315 370 PMID: 15994369

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Keywords: [Ala2,8,9,11,19,22,24,25,27,28]-VIP, supplier, selective, VPAC1, agonists, Vasoactive, Intestinal, Peptide, Receptors, VIP, VIP, Receptors, Tocris Bioscience

Citations for [Ala2,8,9,11,19,22,24,25,27,28]-VIP

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Currently there are no citations for [Ala2,8,9,11,19,22,24,25,27,28]-VIP.

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