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Inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 289.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||34.57 mL||172.84 mL||345.67 mL|
|0.5 mM||6.91 mL||34.57 mL||69.13 mL|
|1 mM||3.46 mL||17.28 mL||34.57 mL|
|5 mM||0.69 mL||3.46 mL||6.91 mL|
References are publications that support the biological activity of the product.
Chen et al (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J.Biol.Chem. 286 43951 PMID: 22020937
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Keywords: A 484954, A 484954 supplier, A484954, eukaryotic, elongation, factor-2, kinase, eef2k, inhibitors, inhibits, CaM, Kinase, 4483, Tocris Bioscience
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