6877002

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Cat.No. 5602 - 6877002 | C17H17NO | CAS No. 433249-94-6
Description: CD40-TRAF6 interaction inhibitor
Chemical Name: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.

Technical Data

M. Wt 251.32
Formula C17H17NO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 433249-94-6
PubChem ID 2291556
InChI Key SARYOFMRLSHZFE-ZHACJKMWSA-N
Smiles CC1=CC=C(C)C(N/C=C/C(C2=CC=CC=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.13 100
ethanol 25.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 251.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.98 mL 19.89 mL 39.79 mL
5 mM 0.8 mL 3.98 mL 7.96 mL
10 mM 0.4 mL 1.99 mL 3.98 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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References

References are publications that support the biological activity of the product.

Chatzigeorgiou et al (2014) Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc.Natl.Acad.Sci.U.S.A. 111 2686 PMID: 24492375


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