Discontinued ProductUnfortunately (2S,3R)-Chlorpheg (Cat. No. 0818) has been withdrawn from sale for commercial reasons.
Reported selective inhibitor of L-homocysteate uptake. Less active than the (2S,3S) isomer.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the products' biological activity.
Chalmers et al (1995) Differential actions of 3-(4-chlorophenyl)glutamic acid stereoisomers and L-trans-pyrrolidine-2,4-dicarboxylic acid upon L-homocysteic acid and L-glutamic acid-induced responses from rat spinal motoneurones. Neuropharmacology 34 1589 PMID: 8788956
Jane et al (1996) Diastereoselective synthesis of all four isomers of 3-(4-chlorophenylglutamic acid: identification of the isomers responsible for the potentiation of L-homocysteic acid-evoked depolarizations in neonatal rat motoneurons. J.Med.Chem. 39 4738 PMID: 8941386
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Keywords: (2S,3R)-Chlorpheg, supplier, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience
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Literature in this Area
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Huntington's Disease Poster
Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.