18A

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Cat.No. 5612 - 18A | C14H11N5O2S | CAS No. 331261-50-8
Description: HIV cell entry blocker
Chemical Name: N-2,1,3-Benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-hydrazinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

HIV cell entry blocker. Binds gp120 and inhibits cell entry for a broad spectrum of HIV isolates. Exhibits no effect on the binding of CD4 or CCR5.

Technical Data

M. Wt 313.33
Formula C14H11N5O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 331261-50-8
PubChem ID 5406107
InChI Key ZZQLQFJBFGKWHX-UHFFFAOYSA-N
Smiles O=C(N/N=C/C1=CC=C(O)C=C1)NC2=CC=CC3=NSN=C32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.33 100
ethanol 3.13 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 313.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.96 mL 31.92 mL
5 mM 0.64 mL 3.19 mL 6.38 mL
10 mM 0.32 mL 1.6 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Herschhorn et al (2014) A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. Nat.Chem.Biol. 10 845 PMID: 25174000


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