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HIV cell entry blocker. Binds gp120 and inhibits cell entry for a broad spectrum of HIV isolates. Exhibits no effect on the binding of CD4 or CCR5.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 313.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.19 mL||15.96 mL||31.92 mL|
|5 mM||0.64 mL||3.19 mL||6.38 mL|
|10 mM||0.32 mL||1.6 mL||3.19 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the biological activity of the product.
Herschhorn et al (2014) A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. Nat.Chem.Biol. 10 845 PMID: 25174000
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Keywords: 18A, 18A supplier, Antivirals, 5612, Tocris Bioscience
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