Tools for PROTAC R&D

PROTACs are heterobifunctional small molecules which induce targeted protein degradation and are modular in design. Below you will find PROTAC components designed for use as building blocks to support PROTAC research and development.

Products
Background
Literature
Cat No Product Name / Activity
6300 Azido-Thalidomide
Azide-functionalized Thalidomide, 'click' ligand for PROTACs
6589 (+)-JQ1 PA
'Click' target ligand for PROTACs; functionalized BET bromodomain inhibitor
6637 Pomalidomide - linker 1
Pomalidomide-PEG2-ethylamine
6466 TC E3 5031
Carboxylic acid-functionalized Thalidomide, Cereblon ligand for PROTACs
6628 TC E3 5032
Precursor to Pomalidomide-based PROTACs
6467 Thalidomide - linker 1
Thalidomide-PEG3-ethylamine
6468 Thalidomide - linker 2
Thalidomide-PEG4-ethylamine
6469 Thalidomide - linker 3
Thalidomide-alkylC4-amine
6627 Thalidomide - linker 4
Thalidomide-alkylC6-amine
6463 VH 032 - linker 1
VH 032-PEG3-amine
6464 VH 032 - linker 2
VH 032-PEG4-amine
6465 VH 032 - linker 3
VH 032-alkylC4-amine
6462 VH 032, amine hydrochloride
Functionalized VHL ligand for PROTACs

Related Categories

    PROTACs are heterobifunctional small molecules which induce targeted protein degradation and are modular in design. Below you will find PROTAC components designed for use as building blocks to support PROTAC research and development.

    PROTACs, designed to induce proteasome dependent degradation of a target protein, are modular in design and consist of three covalently linked components:

    • E3 ubiquitin ligase ligand
    • Linker
    • Ligand for a target protein of interest

    They have successfully been designed and utilized to induce targeted degradation of a variety of different proteins, including bromodomain-containing proteins, ligases, kinases, and RTKs. Application of this approach to achieve knockdown of further targets is currently an area of active research.

    Tocris provide building blocks to support PROTAC research and development. Our range of PROTAC components contain functional handles for easy conjugation to ligands/linkers of interest. Included in this range are the most effective and commonly used E3 ubiquitin ligase ligands, functionalized at positions known not to interfere with binding affinity. E3 ligase ligands conjugated to common linker groups are also supplied.

    Require a different derivative? Get in touch.

    Literature for Tools for PROTAC R&D

    Tocris offers the following scientific literature for Tools for PROTAC R&D to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    New Product Guide (Spring/Summer 2018)

    Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

    • 7-TM Receptors
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