Tools for PROTAC R&D

PROTACs are heterobifunctional small molecules which induce targeted protein degradation and are modular in design. Below you will find PROTAC components designed for use as building blocks to support PROTAC research and development.

Products
Background
Cat No Product Name / Activity
6300 Azido-Thalidomide
Click-functionalized thalidomide
6466 TC E3 5031
Functionalized cereblon ligand for PROTACs
6467 Thalidomide - linker 1
Functionalized cereblon ligand for PROTACs; incorporates an E3 ligase ligand plus a PEG linker
6468 Thalidomide - linker 2
Functionalized cereblon ligand for PROTACs; incorporates an E3 ligase ligand plus a PEG linker
6469 Thalidomide - linker 3
Functionalized cereblon ligand for PROTACs; incorporates an E3 ligase ligand plus a short alkyl linker
6463 VH 032 - linker 1
Functionalized VHL ligand for PROTACs; incorporates an E3 ligase ligand plus a PEG linker
6464 VH 032 - linker 2
Functionalized VHL ligand for PROTACs; incorporates an E3 ligase ligand plus a PEG linker
6465 VH 032 - linker 3
Functionalized VHL ligand for PROTACs; incorporates an E3 ligase ligand plus a short alkyl linker
6462 VH 032, amine hydrochloride
Functionalized VHL ligand for PROTACs

Related Categories

    PROTACs are heterobifunctional small molecules which induce targeted protein degradation and are modular in design. Below you will find PROTAC components designed for use as building blocks to support PROTAC research and development.

    PROTACs, designed to induce proteasome dependent degradation of a target protein, are modular in design and consist of three covalently linked components:

    • E3 ubiquitin ligase ligand
    • Linker
    • Ligand for a target protein of interest

    They have successfully been designed and utilized to induce targeted degradation of a variety of different proteins, including bromodomain-containing proteins, ligases, kinases, and RTKs. Application of this approach to achieve knockdown of further targets is currently an area of active research.

    Tocris provide building blocks to support PROTAC research and development. Our range of PROTAC components contain functional handles for easy conjugation to ligands/linkers of interest. Included in this range are the most effective and commonly used E3 ubiquitin ligase ligands, functionalized at positions known not to interfere with binding affinity. E3 ligase ligands conjugated to common linker groups are also supplied.

    Require a different derivative? Get in touch.