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Tocriscreen Toolboxes

The Tocriscreen toolboxes are collections of biologically active compounds from the Tocris range that target specific areas of research. Compounds included have the same proven solubility, purity and stability as the products found throughout the Tocris catalog.

Products
Background
Literature

Libraries
Cat No Product Name / Activity
6268 Tocriscreen Kinase Inhibitor Toolbox
A library of 160 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)
5060 Tocriscreen Stem Cell Toolbox
80 Stem Cell modulators supplied pre-dissolved in DMSO (250 μL 10 mM solutions)

The Tocriscreen Toolboxes are collections of biologically active compounds from the Tocris range that target specific areas of research. Compounds included have the same proven solubility, purity and stability as the products found throughout the Tocris catalog.

For a full list of the compounds available in Tocriscreen Kinase Inhibitor Toolbox I and II, please complete our compound library enquiry form.

Graphs for Tocriscreen Toolbox Target Coverage

Graph showing Kinases targeted by products in Tocriscreen Kinase Inhibitor Toolbox I and II
Kinase Toolbox I and II

Tocriscreen Kinase Toolbox I and II contain 160 compounds that target 65 different kinases. Click on the graph for an overview of the kinases covered.

Literature for Tocriscreen Toolboxes

Tocris offers the following scientific literature for Tocriscreen Toolboxes to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Compound Libraries & Toolboxes

Compound Libraries & Toolboxes

This brochure gives an overview of the unique TocriscreenTM compound libraries and toolboxes available from Tocris, including the Tocriscreen Plus, and toolboxes for the study of epigenetics, kinases and stem cells.

  • Tocriscreen Plus & Plus Mini
  • Custom Libraries
  • FDA-Approved Compounds
  • Tocriscreen Toolboxes
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Epigenetics in Cancer

Epigenetics in Cancer Poster

Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Stem Cell Workflow

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.