Sir2-like Family Deacetylases

Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3233 AGK 2
Selective SIRT2 inhibitor
4754 AK 7
Selective SIRT2 inhibitor; brain penetrant
2780 EX 527
Selective SIRT1 inhibitor
4127 Salermide
SIRT1 and SIRT2 inhibitor
5457 SirReal 2
Selective inhibitor of SIRT2
3521 Sirtinol
Selective sirtuin family deacetylase inhibitor
1542 Splitomicin
Sir2p inhibitor

Activators

Cat No Product Name / Activity
4590 Honokiol
SIRT3 activator; also blocks NF-κB activation.
1418 Resveratrol
SIRT1 activator
5667 YK 3-237
SIRT1 activator

Related Targets

    Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis.

    In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways.

    Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacetylases are involved in the normal ageing process through their role in resistance to cellular stress.

    Literature for Sir2-like Family Deacetylases

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Neurodegeneration

    Neurodegeneration Product Guide

    A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

    • Alzheimer's disease
    • Parkinson's disease
    • Huntington's disease

    Sir2-like Family Deacetylase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    SIRT1 Human SIRT1 NM_012238 Q96EB6
    Mouse Sirt1 NM_019812 Q923E4
    Rat Sirt1 NM_001107627 XP_228146
    SIRT2 Human SIRT2 NM_012237 Q8IXJ6
    Mouse Sirt2 NM_022432 Q8VDQ8
    Rat Sirt2 NM_001008368 Q5RJQ4
    SIRT3 Human SIRT3 NM_001017524 Q9NTG7
    Mouse Sirt3 NM_022433 Q8R104
    Rat Sirt3 NM_001106313 XP_215124
    SIRT4 Human SIRT4 NM_012240 Q9Y6E7
    Mouse Sirt4 XM_988059 Q8R216
    Rat Sirt4 NM_001107147 XP_222243
    SIRT5 Human SIRT5 NM_012241 Q9NXA8
    Mouse Sirt5 NM_178848 Q8K2C6
    Rat Sirt5 NM_001004256 Q68FX9
    SIRT6 Human SIRT6 NM_016539 Q9UQD1
    Mouse Sirt6 NM_181586 P59941
    Rat Sirt6 NM_001031649 Q4FZY2
    SIRT7 Human SIRT7 NM_016538 Q9NRC8
    Mouse Sirt7 NM_153056 Q8BKJ9
    Rat Sirt7 NM_001107073 XP_221204