Sensory Neuron-Specific Receptors

Sensory Neuron-Specific Receptors (SNSRs) are a newly identified group of G-protein-coupled receptors that are exclusively localized in a subset of small dorsal root and trigeminal sensory neurons. SNSRs are involved in pain modulation.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1763 BAM (8-22)
Selective agonist for the sensory neuron specific receptor (SNSR)
1650 BAM 22P
Agonist at the sensory neuron specific receptor (SNSR). Also opioid receptor agonist

Modulators

Cat No Product Name / Activity
5738 ML 382
MrgX1 (SNSR4) positive allosteric modulator

Sensory Neuron-Specific Receptors (SNSRs) are a newly identified group of G-protein-coupled receptors that are exclusively localized in a subset of small dorsal root and trigeminal sensory neurons. SNSRs are involved in pain modulation, but their precise mechanism of action has not yet been eluded as rodent orthologs have yet to be clearly defined. Proposed actions include modulation of neuronal calcium and potassium channels and inhibition of presynaptic firing.

Literature for Sensory Neuron-Specific Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Sensory Neuron-Specific Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
SNSR1 Human MRGPRX3 NM_054031 Q96LB0
SNSR4 Human MRGPRX1 NM_147199 Q96LB2
Mouse Mrgprx1 NM_207540 Q8CIP3
Rat Mrgprx1 NM_172158 Q8R4G1
SNSR6 Human MRGPRX4 NM_054032 Q96LA9