Natriuretic Peptide Receptors

Supporting information

Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.

Natriuretic peptide receptors bind α-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is the homeostasis of body fluid volume.

To view external sources of pharmacological information for Natriuretic Peptide Receptors, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NPR1 Human NPR1 NM_000906 P16066
Mouse Npr1 NM_008727 P18293
Rat Npr1 NM_012613 P18910
NPR2 Human NPR2 NM_003995 P20594
Mouse Npr2 NM_173788 Q6VVW5
Rat Npr2 NM_053838 P16067
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Literature for Natriuretic Peptide Receptors

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