Melanocortin (MC) Receptors

Supporting information

Melanocortin receptors are activated by members of the melanocortin family: α-, β- and γ-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5 subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

To view external sources of pharmacological information for Melanocortin (MC) Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MC1 Human MC1R NM_002386 Q9UN60
Mouse Mc1r NM_008559 Q01727
Rat Mc1r XM_226554 XP_226554
MC2 Human MC2R NM_000529 Q01718
Mouse Mc2r NM_008560 Q64326
Rat Mc2r AF547168 Q8CIX6
View all Melanocortin Receptor Gene Data »

Literature for Melanocortin (MC) Receptors

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