Neuromedin U Receptors

Supporting information

Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes: NMU1 and NMU2. The two subtypes have distinct tissue distributions: NMU1 is expressed in the periphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system (especially in the substantia nigra, medulla oblongata and pontine reticular formation).

NMU receptors mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human genes encoding NMU1 and NMU2 are located on chromosomes 2q37.1 and 5q33.1 respectively.

To view external sources of pharmacological information for Neuromedin U Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NMU1 Human NMUR1 NM_006056 Q9HB89
Mouse Nmur1 NM_010341 O55040
Rat Nmur1 NM_023100 Q9JJI5
NMU2 Human NMUR2 NM_020167 Q9GZQ4
Mouse Nmur2 NM_153079 Q8BZ39
Rat Nmur2 NM_022275 Q9ESQ4

Literature for Neuromedin U Receptors

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