Neuropeptide FF/AF Receptors

Supporting information

Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein-coupled receptors that are divided into two subtypes; NPFF1 and NPFF2. NPFF receptors act through inhibition of adenylyl cyclase and activation of phospholipase C and are coupled to voltage-gated N-type calcium channels. NPFF receptors have been implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception through modulation of the opioid system.

NPFF receptors are distributed across the central nervous system, but each subtype has specific localizations. NPFF1 are found in their highest concentrations in the septum, nucleus of the tractus solitarius and hypothalamus, suggesting their participation in neuroendocrine functions. NPFF2 are found in their highest concentrations in the diencephalon and superficial layers of the spinal cord, suggesting their participation in the modulation of pain. The human genes encoding NPFF1 and NPFF2 receptors are located on chromosomes 4q21 and 10q21-22 respectively.

To view external sources of pharmacological information for Neuropeptide FF/AF Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NPFF1 Human NPFFR1 NM_022146 Q9GZQ6
Mouse Npffr1 AY255578 Q80T60
Rat Npffr1 NM_022291 Q924G9
NPFF2 Human NPFFR2 NM_004885 Q9Y5X5
Mouse Npffr2 NM_133192 Q924H0
Rat Npffr2 NM_023980 Q9EQD2

Literature for Neuropeptide FF/AF Receptors

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